UEG Week 2025: Microplastics Impact Human Gut Microbiome

At UEG Week 2025, new research highlights the influence of microplastics on the human gut microbiome. These plastic particles, smaller than 5mm, are linked to changes in gut bacteria that may associate with depression and colorectal cancer. Conducted by the microONE project, this study marks a significant step in understanding microplastics' health impacts.

Researchers from CBmed, alongside international partners, exposed gut microbiome cultures from healthy volunteers to common microplastics such as polystyrene and polyethylene. Altered microbial activity was indicated by increased acidity, despite unchanged bacterial cell counts.

Microplastic exposure led to specific shifts in bacterial composition, particularly within the phylum Bacillota, crucial for gut health. These changes in bacterial makeup and chemical production may have potential disease implications, highlighting the need for further investigation.

Lead author Christian Pacher-Deutsch emphasized the ubiquity of microplastics in daily life and their uncertain health effects, advocating precautionary measures to reduce exposure.